Packaging label for Spravato, a nasal spray medication containing esketamine, produced by Janssen Pharmaceuticals, with rainbow-colored design elements.

We are happy to be able to provide you with SPRAVATO® (esketamine) CIII, a nasal spray that can be taken with an oral antidepressant to treat treatment-resistant depression (TRD) in adults and depressive symptoms in adults with MDD with acute suicidal ideation or behavior. 

Speak with your Prescriber to see if Spravato is right for you.

A nasal spray device labeled Spravato containing esketamine, with a blue cap and white body, against a white background.
A young woman with red curly hair lying on a bed, looking to the side with a thoughtful expression. There is a quote overlay on the left side of the image from Nicole, a 23-year-old from St. Peters, MO, talking about starting her day feeling neutral with SPRAVATO® for treatment-resistant depression.
Three healthcare professionals in white coats talking, with one holding a clipboard.
  • SPRAVATO® is a prescription medicine, used along with an antidepressant taken by mouth to treat Depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions.

    SPRAVATO® offers a different approach and is the only nasal spray treatment indicated for treatment-resistant depression (TRD).

    SPRAVATO® is the only FDA-approved nasal spray for TRD.

    SPRAVATO® is an NMDA receptor antagonist that is believed to work differently by acting on a pathway in the brain that affects glutamate.

    The exact way SPRAVATO® works is not fully understood

    Limitations of Use:

    SPRAVATO® is not for use as a medicine to prevent or relieve pain (anesthetic). It is not known if SPRAVATO® is safe or effective as an anesthetic medicine.

    It is not known if SPRAVATO® is safe and effective for use in preventing suicide or in reducing suicidal thoughts or actions. SPRAVATO® is not for use in place of hospitalization if your healthcare provider determines that hospitalization is needed, even if improvement is experienced after the first dose of SPRAVATO®.

    It is not known if SPRAVATO® is safe and effective in children.

  • If you’ve taken two or more oral antidepressants and still experience symptoms of depression, you might have treatment-resistant depression(TRD).

    It might be time to talk to your doctor about a different treatment approach. See what makes SPRAVATO® different and learn more about other patients’ experiences with SPRAVATO®.

    Click HERE to learn more.

  • If you have treatment-resistant depression (TRD), you may benefit from adding SPRAVATO® to your current oral antidepressant.

    Call our office to see if adding SPRAVATO® may be right for you, and discover more about what the full SPRAVATO® treatment experience could look like for you.

A woman sitting in a yellow chair drinking a glass of water, with a healthcare professional standing nearby.
A woman holding a mug, standing in a kitchen with sunlight coming through the window, labeled as actor portrayal. The image features a promotional webpage for SPRAVATO, with text discussing treatment options for depression and guidance for talking to a healthcare provider.
  • There is a study that suggests after the third oral antidepressant, remission rates dropped below 14%. If you’ve tried two or more oral antidepressants and are still experiencing depressive symptoms, you may have treatment-resistant depression and it may be time for something different.

  • Treatment-resistant depression is defined as not responding to two or more antidepressants of adequate dose and duration. If your doctor has diagnosed you with treatment-resistant depression, you may benefit from treatment with a different kind of medication.

  • It is helpful to understand the clinical trials for any medication you consider taking.

  • It is important to understand the potential side effects of any medication you consider taking. To help ensure safety, SPRAVATO® is available only through a restricted distribution program called the SPRAVATO® Risk Evaluation and Mitigation Strategy (REMS) Program.

  • Yes. Dagenhart Health and Wellness is a certified SPRAVATO® treatment center.

    SPRAVATO® is only available at certified treatment centers and must be self-administered under the supervision of a healthcare provider.

  • Cost can sometimes impact a patient’s treatment journey; however, there may be affordability programs available to help eligible patients.

    Click HERE for additional information.

When deciding to explore mental health medications, you don’t have to make the decision alone.